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The risk is much lower for those taking metformin alone

Some individuals benefit from a gradual transition approach rather than stopping suddenly

Severe pain in the right upper abdomen, especially if it radiates to the shoulder blade, lasts more than a few hours, or is accompanied by fever, nausea, or vomiting, may indicate acute cholecystitis or other gallstone complications

[14] It's also important to emphasize that tirzepatide is not FDA-approved for the treatment of hypertension, and should not replace standard antihypertensive therapy