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Lina et al
The cartridge preserves sterility across the dosing window because it remains sealed until the needle is inserted
In the context of acquired resistance, PDX models can be subjected to repeated drug exposure to mimic disease progression observed in patients transitioning from initial sensitivity to resistance
The implications include altered metabolism of several biomolecules and enzyme systems of well-established pathophysiologic relevance such as vitamins B6, B9 (folate), B12, D3, NO, lipids, amino acids, proteins, DNA, cytochrome P-450 and other enzyme systems, HO, and homocysteine
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