8 Challenges and Considerations in Multi-Agonist Therapy Despite their advantages, GLP-1-based therapies face several challenges in adolescent populations: Gastrointestinal Side Effects: Nausea, vomiting, diarrhea, and constipation are common adverse events, especially during dose escalation
Semaglutide, marketed under the brand names Ozempic and Wegovy, and Tirzepatide, marketed as Mounjaro and Zepbound, are both glucagon-like peptide-1 (GLP-1) receptor agonists
Allergic Reactions: Rash, swelling, or breathing difficulties (very rare)
Unlike GLP-1 or GIP analogs that target incretin receptors, Cagrilintide operates as a non-selective agonist of both the amylin receptor (AMYR) complexes and calcitonin receptors (CTR)