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Animal studies have emphasized the efficiency of the glymphatic system in purging waste from the brain, with peak effectiveness during sleep [14], particularly at night [204], and reduced efficacy observed in animal models of hypertension [205]

5 July 2023

(ii) Cu 2+ induces the secretion of acidic SMase from leukocytes which in turn leads to accumulation of erythrocytic ceramide [131] and (iii) treatment of erythrocytes with extracellular SMase resulted in ceramide-associated alterations in membrane-cytoskeleton interactions and membrane organization [125]