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The data were corrected for the non-enzymatic reaction rates and analyzed by non-linear regression using GraphPad Prism 8 software Results and discussion A spectrophotometric assay of the reaction of glutathione with JS-K (Fig
10.1093/cid/ciaf577 Clin
Retatrutide Clinical Results: Complete Data From Every Trial (2026) Complete efficacy and safety data from all six completed retatrutide trials Phase 2, TRIUMPH-1 through TRIUMPH-4, and TRANSCEND-T2D-1
The most common gastrointestinal side effects include: Nausea : Reported in 15-44% of patients (higher rates at Wegovy 2.4 mg), typically most pronounced during dose escalation Diarrhea : Affects approximately 8-30% of users, ranging from mild to moderate severity Vomiting : Occurs in 5-24% of patients (higher rates at Wegovy 2.4 mg), often associated with rapid dose increases Abdominal pain : Experienced by 5-20% of patients, usually described as cramping or discomfort Constipation : Paradoxically affects 3-24% despite the medication's effects on motility Dyspepsia and gastroesophageal reflux : Related to delayed gastric emptying These effects result from semaglutide's pharmacologic action on GLP-1 receptors throughout the gastrointestinal tract
