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Tirzepatide tends to produce greater weight loss on average (20.9% in SURMOUNT-1 versus 14.9% in STEP 1), which may translate to slightly more pronounced menstrual effects
The basic reason GLP-1R agonism works for weight loss is that GLP-1 regulates appetite
DPP-4 (not described in detail in this article) is the enzyme responsible for degrading native GLP-1 and GIP in the body
What's more, there's even evidence to suggest that increasing levels of glutathione may lead to a greater lifespan
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