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It's about restoring or amplifying what should already be happening which is why the side effect profiles of most therapeutic peptides are generally favorable, and why this category of treatment has attracted significant clinical research interest over the past decade

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110,111 Causes of ER expression loss include epigenetic regulation, hypoxia, overexpression of epidermal growth factor receptor (EGFR) or human epidermal growth factor receptor 2 (HER2), and dysregulation of tumor suppressors such as p53 and pRb2/p130

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