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The compounded formulation offers flexibility in dosing regimens, as determined necessary by the patients prescribing physician, with various concentrations available to accommodate different patient needs and treatment protocols

362 Additionally, copper ionophores or copper-ligand complexes (e.g., elesclomol) are being explored to selectively induce cuproptosis in tumor cells with active mitochondrial metabolism

453 Novel agents, including antibodies, ADCs, DDR inhibitors, epigenetic therapies, PROTACs, and nanomedicine delivery platforms, offer new opportunities for resistance-targeting interventions

To date, more than 100 natural medicine monomers have been reported to activate the GSH system by several mechanisms to protect the heart from oxidative stress