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However, they also explain why gastrointestinal side effects are among the most commonly reported

It has been demonstrated that, together with the regulation of CPT1 by malonyl-CoA, acetylation of CACT plays a crucial role in the control of the influx of fatty acyl units into mitochondria 57

The researchers acknowledged study limitations, including possible outcome misclassification because of the use of diagnostic codes not validated in claims data, potential underrecording of GI adverse events in the claims databases, and not being able to rule out possible residual confounders from certain factors like BMI

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