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This effect is achieved in the following ways
Notice that in all cases the percentage of functional hepatocytes continues to decrease for some time after the NAC rescue
347,365 Additionally, mitochondrial augmentation therapywhere autologous CD34 + hematopoietic cells are augmented with maternally derived healthy mitochondriahas shown promising outcomes for mtDNA deletion syndromes like Pearson syndrome and Kearns-Sayre syndrome
J Clin Endocrinol Metab (2021) 106(3):91221
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