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In the brain, particularly the hypothalamus, it reduces appetite and creates earlier satiety

Sci Rep 11(1):22063

Additionally, receptor density varies genetically: some individuals have naturally higher GLP-1 receptor expression, making them more responsive to lower doses, while others require higher doses (10mg15mg) to achieve equivalent food noise suppression

Concomitantly, autophagy was reported to also reduce the hepatocyte apoptosis caused by steatosis and endoplasmic reticulum stress, possibly through the GLP-1RA-stimulated GLP-1R-mediated activation of the EB transcription factor of the autophagy-lysosome pathway, thus reducing the accumulation of liver lipids (201)