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Underlying Medical Conditions Liver disease Kidney disease Blood disorders Certain cancers 3

GLP-1 inhibits glucagon release (which slows down the release of sugar into the blood so that you burn more fat), slows down gastric emptying (makes you feel full), and lowers the desire for food intake (because you feel full)

Semaglutide, on the other hand, is a medication primarily prescribed for people with type 2 diabetes and, more recently, for those who need to lose weight as part of managing certain health risks

NICE recommends reviewing GLP-1 treatment at six months and continuing only with meaningful HbA1c reduction (11 mmol/mol) and 3% weight loss