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Microdosing semaglutide Some prescribers use doses below the standard starting point (less than 0.25 mg) for patients who are particularly sensitive to GLP-1 medications or who have a history of severe nausea with other medications

PubMed alternative-therapies.com 5

The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location