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Because medications have highlighted just how hard it is to maintain weight loss when treatment depends on a drug you may need forever

Second, the off-label adoption pattern that the longevity reframing will inevitably accelerate is going to produce the next wave of monitoring, dosing, and selection problems, patients without obesity or diabetes do not have the diagnostic anchors (BMI, A1c, insulin resistance markers) that frame the on-label conversation, and the clinical infrastructure for managing GLP-1 therapy in metabolically healthy users is, charitably described, thin

One paper suggested that GLP-1s may improve some gut health symptoms (such as abdominal pain) but worsen others (such as regularity and constipation)

While GLP-1 and GIP handle blood sugar and satiety, Glucagon stimulates the liver to release stored energy and burn fat