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Small intestinal metabolism is central to whole-body insulin resistance
Nausea ranks as the most frequently observed effect, particularly during dose initiation and escalation phases
To better understand the human relevant pathways modulated by semaglutide, we analyzed gene expression changes in microglia, endothelial cells, and pericytes, focusing on their overlap with AD-associated genes
Percent change in weight from baseline to week 72 Primary outcome: Results Among participants with obesity but without diabetes, treatment with tirzepatide was superior to treatment with semaglutide with respect to reduction in body weight and waist circumference at week 72
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