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Walters JRF, Tasleem AM, Omer OS, et al
Melasma causes symmetrical patches on cheeks, forehead, and upper lip
Importantly, proteolytic cleavage of SPARC (secreted protein acidic and rich in cysteine), a matricellular protein abundantly expressed at sites of vascular injury and tissue remodeling, generates GHK-containing fragments that promote endothelial cell proliferation and neovascularization
Inflammation in the knee is not always the enemy
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