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Stimulation of sulfated glycosaminoglycan synthesis by the tripeptide-copper complex Glycyl-L-histidyl-L-lysine-Cu2+ 8

These experiments indicated a pH optimum of pH 7.58 in the presence of 400 M MSA and 2 mM NAD +

Exp Physiol 108:1227 Badenoch JB, Rengasamy ER, Watson C, Jansen K, Chakraborty S, Sundaram RD, Hafeez D, Burchill E, Saini A, Thomas L, Cross B, Hunt CK, Conti I, Ralovska S, Hussain Z, Butler M, Pollak TA, Koychev I, Michael BD, Holling H, Nicholson TR, Rogers JP, Rooney AG (2022) Persistent neuropsychiatric symptoms after Covid-19: a systematic review and meta-analysis

The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin