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The gap between clinical trial efficacy and real-world effectiveness represents an important consideration for healthcare providers and patients
Intramuscular injection of palmitic acid-conjugated Exendin-4 loaded multivesicular liposomes for long-acting and improving in-situ stability
Biological validation demonstrated superior therapeutic outcomes compared to monotherapy or free drug combinations, including enhanced apoptosis induction, elevated reactive oxygen species generation, cell cycle arrest in breast cancer cells, and significant tumor regression with metastasis suppression in murine models without systemic organ toxicity
De Vadder F, Kovatcheva-Datchary P, Goncalves D, Vinera J, Zitoun C, Duchampt A (2014) Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits
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