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The MTHFR gene provides the instructions for producing the MTHFR enzyme
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46 Drug-Drug Interactions: Saxagliptin is a strong CYP3A4 inhibitor, so its labeling recommends limiting saxagliptin to 2.5 mg daily in patients taking other strong CYP3A4 inhibitors, such as ketoconazole, based on the risk of increased saxagliptin levels
All efforts were made to minimize number of animals and to lower their sufferings
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