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Like rifampin, aminoglutethimide substantially reduced tamoxifen AUC (by 73%), and the effect of aminoglutethimide on endoxifen AUC (93% decrease) was even greater than found for rifampin in the study cited above
As shown on the right panel, aspirin irreversibly inhibits COX activity by acetylation of a serine residue in the active site for COX (SER 529 in COX-1 & SER 516 in COX-2)
Ng, The Effects of Human GH and Its Lipolytic Fragment (AOD 9604) on Lipid Metabolism Following Chronic Treatment in Obese Mice and 3-AR Knock-Out Mice, Endocrinology, Volume 142, Issue 12, 1 December 2001, Pages 51825189
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