Drug Development and Industrial Pharmacy, 45(9), 14031420
\Safety Profile: Demonstrated safety comparable to placebo in human clinical trials (Human Study)
Edlow BL, Keene CD, Perl DP, Iacono D, Folkerth RD, Stewart W, Mac Donald CL, Augustinack J, Diaz-Arrastia R, Estrada C, Flannery E, Gordon WA, Grabowski TJ, Hansen K, Hoffman J, Kroenke C, Larson EB, Lee P, Mareyam A, McNab JA, McPhee J, Moreau AL, Renz A, Richmire K, Stevens A, Tang CY, Tirrell LS, Trittschuh EH, van der Kouwe A, Varjabedian A, Wald LL, Wu O, Yendiki A, Young L, Zllei L, Fischl B, Crane PK, Dams-O'Connor K
IGF-IR promotes tumor growth, anoikis evasion, and metastasis PI3K is a classical lipid kinase that catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P 3 ) [44]