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Mechanistically, stable-isotope tracing demonstrates that exogenous formate is assimilated by tumor-infiltrating CD8 T cells into the folate-dependent 1 C network, supplying 10-formyl-THF for de novo purine synthesis and thereby sustaining clonal expansion and effector programming under checkpoint pressure [71]
Rybelsus does not directly cause irregular periods, but metabolic improvements such as weight loss and enhanced insulin sensitivity may indirectly influence menstrual patterns
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Payers hesitation to cover GLP-1s for weight loss is also fueled by employer plan sponsor concerns about up-front costs of the drugs
