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However, in this study, a lysosome-related inhibitor curtailed the transport of LG/TD-NF to the basolateral side of the membrane by about 14.1 7.8% (Figure 4E)
Although these are rough estimates that rest upon assumptions about the relative rates and ability to detect DILI between different drugs (and between the US and Iceland), the EID provides informative rates for these rare events and likely explains why the risk of DILI may be missed in registration trials of new drugs which may enroll fewer than 1,000-3,000 patients
No significant differences in efficacy between the injectable and oral forms are evident
Preclinical translation of the pharmacokinetics and pharmacodynamics of peptide therapeutics
