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Because GLP-1 receptors saturate, layering a second GLP-1 agonist yields diminishing returns while side effects continue to scale

The body has a limited number of hormone receptors

In this study, although we proved that ex vivo nitric oxide- and endothelium-related vasodilation in normal large vessel was induced only by BPC 157 at high concentration, it could not be ruled out that BPC 157 at low concentration might counteract the imbalanced blood pressure under an in vivo diseased condition through a currently unknown mechanism

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