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Staff cited inadequate substance characterization, uncertain product quality, insufficient evidence of effectiveness for ulcerative colitis, sparse human safety data, and unresolved risks such as immunogenicity, aggregation, impurities, and long-term exposure
Eur J Hum Genet
Second, the inability to quantify central nervous system (CNS) GSH concentrations in vivo has substantially hindered therapeutic trials targeting CNS augmentation
The samples were centrifuged at 13000 g for 10 min at 4 C and the supernatant was collected and detected by HPLC to analyze the biostability of M-CuP and D-CuP against proteinase K
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