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As use has expanded, concerns have grown regarding serious side effects , including severe gastrointestinal injury, kidney complications, gallbladder disease, and vision problems

paper introduced Dihexa as a metabolically stabilized AngIV analogue and reported reversal of scopolamine-induced spatial learning deficits in rats and improved spatial learning in aged rats following oral administration

4.1.6 Intestinal farnesoid X receptor antagonists Accumulating experimental evidence recently accounted for intestinal farnesoid X receptor (FXR) as another potential candidate target to protect against MASLD/MASH (117)

This is the therapeutic dose