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Sci Rep 14 , 13862 (2024)
Gently swirl or roll until completely dissolved, ensuring not to shake the vial, to achieve a concentration of 5 mg/mL
Comparison of inactive-state and active-state CCR8 structures and analysis of the receptor-chemokine interactions allows us to rationalize how signal transmission from CRS2 to the canonical GPCR microswitches 44,45 could occur to enable the outward motion of the intracellular side of TM6, the hallmark of GPCR activation
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