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Nausea, vomiting, diarrhea, constipation, and abdominal pain all occurred more frequently with combination therapy
Subcutaneous Injection Protocol Injections are delivered with a small insulin-size needle into the subcutaneous fat, typically the abdomen or thigh
Mechanism involves NO system modulation (homeostatic regulationupregulating when deficient, moderating when excessive), VEGF/VEGFR2 upregulation for angiogenesis, FAK-paxillin pathway activation for cell migration (40% increase per Chang et al.), and EGR-1 transcription factor upregulation for growth factor sensitivity
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