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However, human evidence remains limited

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mine complain when their nails are too long, it gets uncomfortable for them to walk I've accustomed my cats to enduring this, since they were kittens or since I adopted them, I find that the implements usually sold for claw clipping don't do a quick smooth shear, so I use wire clippers from the hardware store, the kind you might use to make jewelry -- that blunts the claws slightly yet cat has plenty of claw to climb trees, defend self -- front claws only of course -- human nail clippers don't do the job cleanly either could it be that your mild mannered cat became aggressive through fear or pain, and lashed out