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Tirzepatide goes a step further it activates both GLP-1 and GIP receptors, a dual mechanism that produces meaningfully stronger weight loss outcomes in head-to-head trials
Important safety considerations include contraindications in patients with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, caution in those with a history of pancreatitis, increased risk of gallbladder disease, potential for acute kidney injury with dehydration, and possible worsening of diabetic retinopathy with rapid glycemic improvement
