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12 Combinatorial approaches involving DDR inhibitors, epigenetic modulators, metabolic disruptors and immunotherapeutics hold promise for overcoming resistance and achieving durable clinical responses across malignancies

If an ACOS patients symptoms are inadequately controlled with an ICS + LABA combination, the addition of a LAMA should be considered, particularly when recurrent exacerbations occur

Until one does, the correct statement is not that the combination is unsupported by strong evidence but that it is unstudied, which is a different and cleaner claim

Similarly, myelin lipids undergo dynamic renewal to better preserve sheath integrity