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Its receptor GLP-1R is mainly expressed in islet cells in the pancreas, and is also widely expressed in tissues such as stomach, small intestine, heart, kidney, lung and brain
If you cannot commit to daily administration, consider protocols that explicitly include off days (like 5 days on, 2 days off)
Some people carry genetic variants that reduce their sensitivity to these medications, meaning standard dosing may never produce the appetite suppression or metabolic boost others experience
60 Yoshino S, Tagawa T, Awa R, Ogasawara J, Kuwahara H, Fukuhara I
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