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Within-class differences further inform selection, as GLP-1RAs are more strongly associated with reductions in atherosclerotic events, while SGLT2is demonstrate greater benefit in HF and kidney outcomes, with modest blood pressure-lowering effects that may contribute to cardiovascular risk reduction [9]

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Neuropsychopharmacology 35 : S320S321

Fourth, the use of pseudo-observations at zero dose, while methodologically justified to stabilize model behavior at the lower boundary, represents a modeling assumption that may influence extrapolation outside the observed dose range