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In addition to dietary changes, regular exercise, and behavioral therapy, your doctor may recommend medications for weight loss
The weight loss achieved varies by specific medication and dose: semaglutide 2.4 mg (Wegovy) produces approximately 15% weight loss, tirzepatide (Zepbound) up to 15-22%, and liraglutide 3 mg (Saxenda) about 5-8%
They postulate the pain felt by patients is out of proportion to the damage seen, the pain is not just because cartilage over the bone gets worn down. They state the thin rim of the cartilage becomes inflamed and sends pain signals to the body
& Valverde, I
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