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When food remains in the stomach for extended periods of time, patients may develop severe nausea, vomiting, dehydration, malnutrition, abdominal swelling, and painful digestive complications requiring hospitalization or emergency treatment

Incubation of NFT with cell or tissue homogenates, microsomal preparations, or isolated mitochondria revealed one-electron reduction of NFT to yield an NFT radical anion ( NFT ) by flavoprotein-reductases such as xanthine oxidase, aldehyde dehydrogenase, thioredoxin reductase, cytochrome b 5 reductase, and cytochrome P450 reductase (CYPOR) (Miller et al