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Medications that increase or exacerbate melasma
Hydration plays an important role in overall skin health
Strong ghrelin receptor affinity and dual-site activation: GHRP-2 binds to ghrelin receptors expressed both in the hypothalamus and pituitary
However, small-molecule 3 was quite lipophilic (logD 7.4 = 5.7), resulting in high metabolic intrinsic clearance in human liver microsomes (HLM) (CL int = 130 mL/min/kg, Table S4), which would likely lead to a short pharmacokinetic half-life (t 1/2 ) and the requirement for an unacceptably high daily dose in humans
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