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Areas of theoretical concern include: Glycaemic instability , particularly in those on antidiabetic medications Altered lipid metabolism , given GH's effects on fatty acid mobilisation Indirect cardiovascular effects , as elevated heart rate has been observed with glucagon receptor agonism and fluid retention is associated with GH excess [1] [17] There are no formal interaction data linking retatrutide and sermorelin to specific adverse outcomes, but the absence of evidence must not be interpreted as confirmation of safety

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While LEADER and ELIXA were similar in terms of their overall design, there were some major differences between the patient populations enrolled in the two studies