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The SURPASS program (for type 2 diabetes) and SURMOUNT program (for obesity) together enrolled over 20,000 participants across multiple Phase III trials

Tirzepatide, a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist, and Semaglutide, a GLP-1 RA, have shown greater weight loss efficacy than traditional medications like Phentermine/Topiramate (Qsymia), Naltrexone/Bupropion (Contrave), and Phentermine 12,14,15

In some ways, the failure of the first generation of PPAR agonists paved the way for the Ozempic revolution