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No Rebound Hunger or Metabolic Adaptation Appetite suppressants that work through central mechanisms (GLP-1 agonists, sympathomimetics, serotonergic agents) typically create tolerance over time, requiring dose escalation, and often produce rebound hunger when discontinued

Prognostic Factors are: Tumor Size: Tumors larger than 5 cm at diagnosis are associated with significantly worse prognosis

Achieving long-term survival in MMNST is hampered by its tendency to metastasize and recur, and its propensity to involve the spine or other structures, which preclude complete surgical resection [32]

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