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Table of Contents What Cagrilintide and Retatrutide Are and How They Work Approved Uses and Current Clinical Evidence in the UK How These Medicines May Affect Men Specifically Dosage, Administration, and What to Expect Side Effects, Risks, and Safety Considerations Availability on the NHS and Next Steps for Treatment Scientific References Frequently Asked Questions What Cagrilintide and Retatrutide Are and How They Work Cagrilintide is a long-acting amylin analogue that promotes satiety and slows gastric emptying, while retatrutide is a triple agonist targeting GLP-1, GIP, and glucagon receptors to reduce appetite, enhance insulin secretion, and increase energy expenditure

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37 Network Meta-Analysis Percent Weight CFB to 52 Weeks In all populations studied, semaglutide 2.4 mg was associated with a greater percentage weight CFB with 52 weeks of treatment versus all available comparators, except for phentermine 15 mg/topiramate 92 mg in the T2DM population