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52 Orforglipron showed to have a pharmacodynamic and safety profile similar to that of injectable GLP-1 which supported continued clinical development
But heres where it gets interesting semaglutide doesnt just magically transform into a pumpkin at midnight on its expiration date
Common side effects include: Mild to Moderate Side Effects Nausea Vomiting Diarrhea or constipation Abdominal discomfort Appetite changes Headache Less Common Side Effects: Dizziness Fatigue Injection site reactions Temporary hypoglycemia when combined with other diabetes medications Rare but Serious Side Effects: Pancreatitis: Severe abdominal pain that may radiate to the back Gallbladder disease: Increased risk of gallstones Kidney issues: Worsening kidney function in some patients Thyroid tumors: Observed in animal studies, though human risk is unclear To minimize side effects, we recommend: Important Considerations Before Starting Semaglutide Medical History: Not recommended for individuals with a history of pancreatitis or thyroid cancer
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