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Abbreviations AHA: American Heart Association ASCVD: Atherosclerotic cardiovascular disease CI: Confidence interval CMA: A conventional meta-analysis CVD: Cardiovascular disease EASD: European Association for the Study of Diabetes ESC: European Society of Cardiology FPG: Fasting plasma glucose GLP-1RA: Glucagon-like peptide-1 receptor agonists HbA1c: Hemoglobin A1c LVEF: Left ventricular ejection fraction MACE: Major adverse cardiovascular events MD: Mean difference PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses QALY: Quality-adjusted life year RCT: Randomized controlled trial RIS: Required information size RoB2: Risk of bias tool for randomized trials RR: Risk ratio SD: Standard deviation SE: Standard error SGTL-2i: Sodium-glucose co-transporter-2 inhibitors T2DM: Type 2 diabetes mellitus TAU: Treatment as usual TSA: Trial sequential analysis UTI: Urinary tract infection References Low Wang CC, Hess CN, Hiatt WR, Goldfine AB
These challenges primarily arise from tumor metabolic heterogeneity, the activation of compensatory pathways, and potential systemic toxicity
As the next-generation GLP-1 agent, it combines the known advantages of GLP-1s with the activity of amylin
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