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On the other hand, without validation, biomarkers may lead to misdiagnosis and inappropriate treatment, resulting in increased healthcare costs and poor patient outcomes

Metabolic Flux Adaptations During GLP-1 Receptor Agonist Therapy: Redox Implications

The use of GLP-1 drugs without medical supervision, including those obtained without a valid prescription, carries potential health risks and may not be suitable for every patient, even among those with type 2 diabetes or obesity

Elevating GH and downstream IGF-1 also carries broader theoretical concerns including effects on insulin sensitivity and glucose metabolism, and the general caution that any growth-promoting signal warrants care in anyone with a history of, or predisposition to, cancer