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Laboratory studies demonstrate that the peptide was engineered as a fusion with HIV-TAT, a basic and hydrophilic sequence that enables energy-independent cellular uptake, ensuring effective intracellular delivery for precise molecular targeting in experimental settings
While the concern is worth observing, it does not seem to be scientifically proven
Acta 399, 102108
25,26,27 In contrast, mutations in POLE/POLD1 enhance immunogenicity through hypermutation, 28 while excessive copy number alterations often drive immunosuppressive phenotypes and resistance
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