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One study demonstrated that curcumin combined with paclitaxel treatment was superior to paclitaxel-placebo combination therapy in terms of ORR and physical performance after 12 weeks of treatment, and there were also no major safety concerns or reduction in quality of life (Saghatelyan et al., 2020).EGCG synergistically enhances the efficacy of drugs such as 5 - Fluorouracil and cisplatin, and reduces cardiac, renal, and other organ EGCG may synergistically enhance the efficacy of drugs such as 5-fluorouracil and cisplatin and reduce the toxicity in the heart and kidney, but some drugs (e.g., bortezomib, sunitinib) may antagonize EGCG, but clinical evidence is limited, and further validation of their safety and efficacy is needed ( Despite their low bioavailability, oral polyphenols can modulate the intestinal flora through their antimicrobial properties, increasing the proportion of beneficial bacteria in the gut and reducing pathogenic bacteria (Scazzocchio et al., 2020)

the cells from tumor and draining lymph nodes tissue were stained with anti-CD11c-PE, anti-CD80-FITC, and anti-CD86-APC antibodies for 30 min, and further analyzed the ratio of mature dendritic cells (DCs)

J Biol Chem 271:97549758 Mandal PK, Shukla D (2020) KALPANA: advanced spectroscopic signal processing platform for improved accuracy to aid in early diagnosis of brain disorders in clinical setting

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