The following stepwise schedule mirrors the inverse of the titration ladder: | Week | Taper Step | Notes | |---|---|---| | Week 1 to 2 | Reduce from 12 mg to 8 mg | Monitor weight and GI symptoms | | Week 3 to 4 | Remain at 8 mg | Confirm tolerability of step-down | | Week 5 to 6 | Reduce from 8 mg to 4 mg | Expect modest appetite increase | | Week 7 to 8 | Remain at 4 mg | Reinforce dietary structure | | Week 9 to 10 | Reduce from 4 mg to 2 mg | Begin transition plan | | Week 11 to 12 | Final 2 mg injection, then stop | Schedule 4-week follow-up | Patients stopping from an 8 mg maintenance dose begin the taper at that level and follow the same 4 mg and 2 mg steps over 8 weeks
Bianchi R, Cervellini I, Porretta-Serapiglia C, Oggioni N, Burkey B, Ghezzi P, Cavaletti G, Lauria G (2012) Beneficial effects of PKF275-055, a novel, selective, orally bioavailable, long-acting dipeptidyl peptidase IV inhibitor in streptozotocin-induced diabetic peripheral neuropathy
doi: 10.3389/fimmu.2024.1362459 314 SunY
Glutathione doubles as a heavyweight protector against oxidative stress that can also protect the body against chronic inflammation