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By the same time, the FDA approved the use of a equimolar combination of IGF-1 and IGFBP-3 (Mecasermin Rinfabate, iPlex), suggesting that it would be a better choice, seeming as it will require lower doses because of the augmented half-life of the molecule and buffering effect on concentration
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Injections are most often given in the forms of hydroxocobalamin or cyanocobalamin at very high doses
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