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AstraZeneca / Daiichi Sankyo Enhertu Redefines First-Line HER2+ Metastatic Breast Cancer Care Enhertu (trastuzumab deruxtecan), an antibodydrug conjugate, became the first ADC approved for first-line treatment of HER2-positive metastatic breast cancer after delivering a marked improvement in progression-free survival versus the long-standing THP standard in the Phase III DESTINY-Breast09 trial