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Note: Glutathione exists in two formsreduced (GSH) and oxidized (GSSG)
(2021) synthesized a dual-targeting phosphatidylinositol-3-kinase and histone deacetylase inhibitor BEBT-908 that robustly reduces tumor cell proliferation and enhances the efficacy in antiprogrammed cell death protein 1 immunotherapy in mice by triggering immunogenic ferroptosis, demonstrating BEBT-908 would be a potential targeted therapeutic medicine against various cancer types ( Altogether, a better comprehension of ferroptotic function may facilitate the discovery of efficient therapeutic approaches for therapying liver diseases, potentially bringing ferroptosis to the forefront of translational medicine in the future
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