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In a Phase 2 clinical trial published in 2023 in the New England Journal of Medicine (Jastreboff et al.), participants receiving the highest dose of retatrutide lost up to approximately 24% of their body weight over 48 weeks a notably greater reduction than observed with currently approved agents
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Cadet P, Mantione KJ, Zhu W, Kream RM, Sheehan M, et al
Causes vary by age, health status, and genetics, but ovulatory disorders account for one-quarter of infertility diagnoses
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